ABSTRACT
Radiotherapy is one of the most important treatments of high-grade gliomas (HGG).Currently,there has been no consensus on the standards for the delineation of the gross tumor volume (GTV) based on the simulated computed tomography (CT) scanning and conventional magnetic resonance imaging (MRI).As the radiological technology advances,researchers have found that the application of multimodal MRI including 1 H magnetic resonance spectroscopy (1 H-MRS),blood oxygenation level dependent functional MRI (BOLD-fMRI),diffusion-weighted MRI (DWI) and diffusion tensor imaging (DTI) can evaluate the range of HGG invasion and locate the surrounding vital tissues,thereby serving as a supplement for the delineation of target volume and protection of organs at risk.Moreover,multimodal MRI can be utilized to evaluate the clinical efficacy of radiotherapy,detect the radiation-induced injury and differentiate the progressive disease from pseudoprogression.In this article,the application of multimodal MRI in the postoperative radiotherapy for patients with high-grade glioma was reviewed.